Significant of Serum 25-Hydroxyvitamin D and Thyroid Hormones Levels in Pregnant Women in Jordan

Submit Manuscript | http://medcraveonline.com molecular pathways and hence it is important in the pathogenesis of preeclampsia [3,4] and bone development in fetus is linked to a steroid hormone in the form the 25-hydroxyvitamin D(25(OH)D) which introduced in the body by food intake with sufficient supplement of Vitamin D however, the major source of vitamin D is through the skin synthesis through exposure to solar ultraviolet light (UVB) [5] in the range of 280-320 nm which can penetrate skin and promote conversion of 7dehydrocholesterol to pro-vitamin D3 (cholecalciferol) in the skin coupled with oral intake that is less what needed during pregnancy [3]. Despite the source of Vitamin D the final conversion occurs in the liver to maintain the level of 25-hydroxyvitamin D in the body. The 25(OH)D is metabolized in the kidneys by the enzyme 25-hydroxyvitaminD-1a-hydroxylase (CYP27B1) to active form 1,25-dihydroxyvitamin D [1] this product is tightly regulated by plasma levels parathyroid hormone, calcium and phosphorus levels [6]. Vitamin D concentration >30.0 ng/ml (>75,0 nmol/L considered to be sufficient, insufficient level is between 20 and 30ng/mL (50-75nmol/L) and deficient if it is <20ng/mL (<50nmol/L) [7-8].There are many factors influence Vitamin D levels in the body such as geographical zones, dietary patterns, physical environment, seasons, dark skin pigmentation and obesity [9-10].